Perinatal photoperiod associations with bipolar disorder and depression: A systematic literature review and cross-sectional analysis of the UK Biobank database.

Season-of-birth associations with psychiatric disorders point to environmental (co-)aetiological factors such as natural photoperiod that, if clarified, may allow interventions toward prevention. We systematically reviewed the literature concerning season-of-birth and bipolar disorder and depression and explored associations between the perinatal natural photoperiod and these outcomes in a cross-sectional analysis of the UK Biobank database. We used mean daily photoperiod and relative photoperiod range (relative to the mean) in the 3rd trimester and, separately, in the first 3 months post birth as metrics. From review, increased risk of depression with late spring birth is compatible with increased odds of probable single episode-, probable recurrent-, and diagnosed depression (OR 2.85 95 %CI 1.6-5.08, OR 2.20 95 %CI 1.57-3.1, and OR 1.48 95 %CI 1.11-1.97, respectively) with increasing 3rd trimester relative photoperiod range for participants who experienced relatively non-extreme daily photoperiods. Risk of bipolar disorder with winter-spring birth contrasted with no consistent patterns of perinatal photoperiod metric associations with bipolar disorder in the UK Biobank. As natural photoperiod varies by both time-of-year and latitude, perinatal natural photoperiods (and a hypothesized mechanism of action via the circadian timing system and/or serotonergic circuitry associated with the dorsal raphe nucleus) may reconcile inconsistencies in season-of-birth associations. Further studies are warranted.

Patients, Doctors, and Chatbots.

Medical advice is key to the relationship between doctor and patient. The question I will address is "how may chatbots affect the interaction between patients and doctors in regards to medical advice?" I describe what lies ahead when using chatbots and identify questions galore for the daily work of doctors. I conclude with a gloomy outlook, expectations for the urgently needed ethical discourse, and a hope in relation to humans and machines.

Circadian epidemiology: Structuring circadian causes of disease and practical implications.

That disruptions of the body's internal clockwork can lead to negative health consequences, including cancer, is a plausible hypothesis. Yet, despite strong mechanistic and animal support, the International Agency for Research on Cancer (IARC) experts considered epidemiological evidence as limited regarding the carcinogenicity of "shift-work involving circadian disruption" (2007) and "night shift work" (2019). We use directed acyclic graphs (DAGs) to outline a concept of circadian causes that discloses challenges when choosing appropriate exposure variables. On this basis, we propose to move beyond shift-work alone as a direct cause of disease. Instead, quantifying chronodisruption as individual doses can lead to interpretable circadian epidemiology. The hypothesis is that doses of chronodisruption cause disrupted circadian organisation by leading to desynchronization of circadian rhythms. Chronodisruption can be conceptualized as the split physiological nexus of internal and external times. Biological (or internal) night - an individual's intrinsically favoured sleep time window - could be the backbone of circadian epidemiology. In practice, individual doses that cause disrupted circadian organisation are derived from the intersection of time intervals of being awake and an individual's biological night. After numerous studies counted work shifts, chronobiology may now advance circadian epidemiology with more specific dose estimation - albeit with greater challenges in measurement (time-dependent individual data) and analysis (time-dependent confounding).

A systematic review of chronobiology for neonatal care units: What we know and what we should consider.

A Cochrane 2016 review indicated cycled light might benefit neonatal health in hospital. We systematically reviewed chronobiological factors for neonatal health in hospital units, identifying 56 relevant studies on light-dark cycles, feeding, noise, massage therapy, rooming-in, incubators vs. cribs, neonatal units vs. homes, and time-of-day of birth. Empirical evidence for benefits from chronobiology is weaker than expected, including light. Mechanisms of clinical benefits are unclear (e.g., changes to sleep/activity vs. other circadian-regulated processes). Regarding light, studies concerning sleep and circadian-related outcomes predominate; yet, neonatologists may be more interested in weight gain and time spent in hospital. Generalisability of findings is limited as most studies targeted neonates in stable condition and without congenital anomalies. Further research is needed, in particular concerning potential circadian entraining signals such as timing of meals or medications. Longer-term outcomes (regarding e.g., neurodevelopment and infection), and who may be at risk from time-of-day of birth effects and why remain to be explored. Overall, there is promise and ample scope for research into how chronobiological factors affect health in hospitalised neonates.

Rudolph, the kids' ward reindeer: a scoping review of the effects of support animals on the well-being of healthcare staff.

BACKGROUND: Many systematic reviews identify support animals or animal assisted activity as a beneficial and standard practice in several medical disciplines for patients (children, adolescents, and adults) and residents in care homes. A variety of animals are used such as dogs, cats, ponies, horses, alpacas, reindeer, penguins, rabbits, and tarantulas. Our objective was to explore the evidence regarding effects of animal assisted activity on a further population of interest; namely, healthcare staff. METHODS: We asked the question "how do support animals in healthcare settings affect the well-being of healthcare staff?" As an addendum, we were also interested in what - possibly more unique - animals have visited healthcare settings at Christmas time in particular. We conducted a scoping literature review using PubMed and Web of Science (search as of 26 April 2023).  RESULTS: Twenty studies (in the USA, Australia, Europe; dogs: n = 19; cats: n = 1) since 2002 included: studies with biological measures (n = 3), longitudinal survey studies with analyses (n = 5), cross-sectional survey studies with analyses (n = 2), and cross-sectional survey studies with descriptive statistics (n = 10). Overall, animal assisted activities appear to be well-received by staff and there do not seem to be negative impacts on staff well-being. CONCLUSIONS: Relevant positive effects and avenues of research are identified. Our review suggests that, but not exactly how, animal assisted activity benefits staff. Study evidence is limited with most studies being cross-sectional, descriptive, having low participant numbers, and mostly only involving dogs. Nonetheless, the evidence is mostly positive. The potential of animal assisted activities impacting positively on staff well-being warrants systematic research. Gaps in hard-fact-evidence should not deter us - especially at the festive season - to encourage work with, and systematic research regarding, support animals that provide warmth, empathy, comfort, and more in healthcare settings.

Poster presentations and session organization: modern conferences.

Posters are important vectors for science. During the pandemic, poster presentations via virtual platforms came to the fore due to necessary online conferences. For the post-pandemic era, we offer approaches for poster presenters and session organizers at modern, more sustainable conferences, which can be in-person, online, or combined (hybrid) formats.

Christmas and New Year "Dietary Titbits" and Perspectives from Chronobiology.

A historical Christmas card connecting two pioneers of modern chronobiology (Colin Pittendrigh and Jürgen Aschoff) brings together key evolutionary facets of the field at Christmas time. The importance of the field to physiology and medicine is conveyed by the Nobel Prize award in 2017 for discoveries of how body clocks facilitate the temporal organization of physiology across days and nights. Temporal organization can have relevance for dietary Christmas excesses and dietary New Year resolutions. Herein, we examine how diet around Christmas and New Year has been targeted in human health research and we examine published opinion on dietary practice concerning Christmas and New Year using a systematized literature review approach. Thereafter, via a selective literature synthesis regarding time-restricted eating, we explore the chronobiological notion that "when" we eat and drink may make differences in terms of whether we experience weight gain and adverse health effects during and after the festive days. Overall, current Christmas eating is typically detrimental to health in terms of "how much" we consume of "what". Regarding New Year's goal-setting, chronobiology-based advice could be considered insofar as "when" we eat may be a healthier and more sustainable nutritional habit alternative. While we need further studies in humans, individual and public health may benefit during and after Christmas by adhering to plausible principles of chrononutrition. That detrimental nutritional excesses over Christmas may encourage individuals to tackle their eating habits should not be left untapped.

Chronodisruption: Origin, Roots, and Developments of an 18-Year-Old Concept. Comment on Desmet et al. Time-Restricted Feeding in Mice Prevents the Disruption of the Peripheral Circadian Clocks and Its Metabolic Impact during Chronic Jetlag. Nutrients 2021, 13, 3846.

We read with interest the article by Desmet and colleagues entitled "Time-Restricted Feeding in Mice Prevents the Disruption of the Peripheral Circadian Clocks and Its Metabolic Impact during Chronic Jetlag" [...].

Avoiding a crisis at Christmas: a systematic review of adverse health effects or 'Chrishaps' caused by traditional hazard sources and COVID-19.

OBJECTIVE: To complement the 2020 ANZJPH editorial "How COVID-safe Santa can save Christmas". In addition to a concise update regarding SARS-CoV-2/COVID-19, we aimed to explore some risks of Christmas in terms of adverse health effects, which we call 'Chrishaps'. Our overall study question was "which hazards have been scientifically associated with old Christmas essentials such as decoration, gifts, menus, and Santa himself, as well as new challenges associated with COVID-19?" METHOD: We searched the PubMed, Web of Science, and Open Grey databases systematically and Google unsystematically. RESULTS: Thirty-six pertinent articles - most of them case reports or retrospective analyses - documented Chrishaps. CONCLUSION: Overall results suggested that Chrishaps come in different shapes and guises. Implications for public health: Chrishaps pose a potential minor public health threat that should be borne in mind every festive season. Assessing and discussing specific public health implications of Chrishaps requires systematic risk research to be conducted.

Before, During, and After the First Wave of COVID-19: Mortality Analyses Reveal Relevant Trends in Germany and its States until June 2020.

OBJECTIVE: Well-established mortality ratio methodology can contribute to a fuller picture of the SARS-CoV-2/COVID-19 burden of disease by revealing trends and informing mitigation strategies. This work examines respective data from Germany by way of example. METHODS: Using monthly and weekly all-cause mortality data from January 2016 to June 2020 (published by the German Federal Statistical Institute) for all ages,<65 years and≥65 years, and specified for Germany's federal states, we explored mortality as sequela of COVID-19. We analysed standardized mortality ratios (SMRs) comparing 2020 with 2016-2019 as reference years with a focus on trend detection. RESULTS: In Germany as a whole, elevated mortality in April (most pronounced for Bavaria) declined in May. The states of Hamburg and Bremen had increased SMRs in all months under study. In Mecklenburg-Western Pomerania, decreased SMRs in January turned monotonically to increased SMRs by June. Irrespective of age group, this trend was pronounced and significant. CONCLUSIONS: Increased SMRs in Hamburg and Bremen must be interpreted with caution because of potential upward distortions due to a "catchment bias". A pronounced excess mortality in April across Germany was confirmed and a hitherto undetected trend of increasing SMRs for Mecklenburg-Western Pomerania was revealed. To meet the pandemic challenge and to benefit from research based on data collected in standardized ways, national authorities should regularly conduct SMR analyses. For independent analyses, national authorities should also expedite publishing raw mortality and population data, including detailed information on age, sex, and cause of death, in the public domain.

Towards a good work-life balance: 10 recommendations from 10 Nobel Laureates (1996-2013).

It can be hard to get the work-life balance right in research and academia. There is no one-size-fits-all recommendation for 'the best work-life balance', as we all have different work-life priorities. But for scientists, at least, Nobel Laureates' thoughts on the matter may prove useful. As such, we describe and discuss, ten recommendations toward a good work-life balance voiced by ten 1996-2013 nobel laureates. "[Peter Medawar] told his young bride, pretentiously, that she had first claim on his love, but not on his time, made her buy her own wedding ring and often also her own Christmas presents. So preoccupied was he with his work that Jean had to be both father and mother to their four children". -Max Perutz (Perutz 2002).